Scientists have apparently identified biological changes that could predict the development of lung cancer in normal airway tissue. Changes in gene and cell activity in the immune system changes.
New research to strengthen the immune system, the lungs against cancer.
A team from the Boston University School of Medicine in Boston has pioneered the study of these findings.
The investigators examined the pre-cancerous lesions in the respiratory tract tissues of smokers or smokers. The team followed a few years to see that individuals became cancerous with their lesions.
In a report on Nature Communication, they explained how precancerous lesions define the ”four molecular subtypes Bir with alt distinct“ tissue and immunity. system differences.
It is possible to detect differences in airway tissue before developing precancerous findings, says Avrum E. Spira, senior study author of medicine, pathology and bioinformatics, Boston University and Johnson & amp; director; Johnson Innovation Lung Cancer Center.
Such findings may also lead to screening and monitoring of people with a high risk of smoking and lung cancer, and they may also lead to new causes. drugs that inhibit or stop lung cancer by strengthening the immune system.
Need for early diagnosis of lung cancer
Lung cancer is the leading cause of cancer deaths worldwide.
The possibility of developing lung cancer during his lifetime is around 1 in 15. For a woman in the US, this figure is around 17. Smokers are lower for non-smokers and the chances are lower.
Lung cancer is one of the reasons why it kills so many people, because the disease usually develops slowly, but often when people notice the symptoms, cancer begins to spread.
It is more difficult to treat when cancer is spread. . It can save many lives to be detected in advance.
Ane Many lung changes will occur before lung cancer develops, de says Jennifer E. Beane, the lead author and associated study author. Medicine at Boston University Medical School.
Understanding the nature of these changes creates an opportunity to kiş identify people at high risk for lung cancer and stop the disease process Bu.
Help the immune system eliminate lesions
New research is related to the relationship between tumors and immunity.
Spire. If so, then it should be possible to yok find a way to come and train the immune system to destroy these lesions, Eğer he adds.
He and his colleagues used iyo deep molecular profiling ler and profil bioinformatics analysis land to investigate biopsied specimens of precancerous lesions from smokers and non-smokers.
They found that many years later, they took too many samples from those who had the highest chance of developing lung cancer. Low activity in specific types of immune cell genes. They referred to the genomic signature of high-risk samples as “Proliferative subtypes Yüksek. "
“The genes involved in interferon signaling and T cell-mediated immunity rol were written”. Among the progressive / permanent lesions of the proliferative subtype, these pathways are compared with regressive lesions, which correlate with a decrease in both natural and adaptive immune cell types. "
Less invasive lung tissue sampling
The team suggests that it is also possible to detect them, using the olan brushing oskop method, which is a less invasive bronchoscope procedure than performing a biopsy, but rather a method to obtain airway samples rather than biopsy.
Although there are still l early days sağ, the findings can provide a simpler way of testing people who have lung cancer incubated and who know how to treat the lungs to intervene. Günler
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