Recent research has looked at human cancer cells placed in mice, human tumor samples, and other analyzes to better understand what drives some aggressive cancers.
Dı A chemical messenger yardımcı can help grow and spread aggressive cancers.
MD, a team at Johns Hopkins Medicine in Baltimore, recently published a study in Cell Reports magazine.
These results include a specific neurotransmitter at higher levels of cancers, which indicate that many are aggressive or higher grade.
High-grade cancer tumors are characterized by faster growth and spreading rates.
Neurotransmitters are chemical messengers that enable neurons to communicate between iler neurons “and send messages to other cells.
In the new study, researchers focused on N-acetyl-aspartyl-glutamate (NAAG), saying that this neurotransmitter may be a new target for treatment. high – grade cancer tumors.
Specifically, their experiments revealed that NAAG was greater in the rapidly developing cancer tumors than in other types of cancer.
NAAG fuels Some aggressive cancers
Initially, scientists used mass spectroscopy to analyze the composition of human Burkitt's lymphoma cells. This technique allows us to evaluate the masses of different components in a working example.
He found that the MYC-guided Burkitt lymphoma expressing MYC gene changes had higher NAAG levels than the MYC-guided lymphoma. . Furthermore, this neurotransmitter was found to be higher in human high-grade ovarian cancer tumors than in primary ovarian cancer tumors.
Cancer: High personalized therapy can improve outcomes In a new study, it is suggested that personalization of cancer treatment may further improve treatment outcomes. Read now
Briefly, fast-growing cancer contained significantly higher NAAG levels than slow-growing cancer tumors.
Moreover, in human brain cancer tumor samples, high-grade tumors had higher NAAG levels than low-grade tumors. tumors.
Looking at the rodent model, they found that the NAAG content increases as the tumor grows. On the other hand, if any tumor shrinks, the NAAG levels are also decreased.
Later, by working with mouse models they implanted human ovarian cancer tumors, scientists tried to fight GCPII activity using an inhibitor called 2-. PMPA.
This allowed them to both reduce tumors and reduce glutmatide concentrations in cancer cells.
Finally, when looking at human-induced pancreatic cancer tumor mice, scientists found that they were able to attack glutaminase, an enzyme that converts glutamine to glutathione, as well as further narrow the cancer tumors with GCPII.
Researchers are likely to stop the production of cell feeders from two sources: NAAG and glutamine.
”Together,“ Dr. Le, mek suggests that these findings strongly combine NAAG plasma concentrations with tumor growth rates, and that NAAG measurements in the peripheral blood should be further investigated in time for the monitor. Regulation of tumor growth during cancer treatment. "
Iyor These results make the NAAG not a potential diagnostic marker, but a prognostic marker, ”he adds.
Le also mentioned earlier research that suggest that glutamine metabolism may help accelerate cancer growth.
Or Seven years ago, we found that glutamine is a major problem in cancer metabolism, and glutamine inhibits the conversion of glutamate. That was the right goal to prevent cancer growth, “says Dr. La.
The post This neurotransmitter helps spread the aggressive tumors appeared first on the Binbon.
Get real time update about this post categories directly on your device, subscribe now.